RNA quality should not be a variable

While sequence and integrity are critical for the success of an RNA product, purity from endotoxin, double stranded RNA (dsRNA), DNA, and proteins are important factors for in vivo studies. As endotoxin and dsRNA are major immunostimulatory molecules, their role can range from beneficial to detrimental: from completely silencing translation to acting as an adjuvant for vaccines. Research groups embarking on drug development often overlook the significance of RNA quality and purity. Knowing these details ensure they are best prepared for success and to effectively reproduce their success.

RNA QC also available as a service. Please inquire for more information.